abstract：:The free radical, or oxidative stress, theory posits that imbalance in cells between prooxidants and antioxidants results in an altered redox state and, over time, an accumulation of oxidative damage. We hypothesized herein that cells with an increasingly prooxidant intracellular environment also might be particularly...

journal_title：Molecular and cellular endocrinology

authors： Chen H,Zhou L,Lin CY,Beattie MC,Liu J,Zirkin BR

更新日期：2010-07-29 00:00:00

abstract：:Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism (CH), a relatively frequent endocrine disease in newborns (1 in 3000-4000 live births). TD is a defect in the organogenesis of the gland resulting in hypoplastic, ectopic or absent-thyroid gland. TD is usually sporadic but mutations in trans...

journal_title：Molecular and cellular endocrinology

authors： Montanelli L,Tonacchera M

更新日期：2010-06-30 00:00:00

abstract：:Mechanisms that preserve endothelial cell (EC) integrity remain elusive, but are critical for new strategies directed against endocrine disorders such as diabetes mellitus (DM). Here we demonstrate in primary cerebral ECs with a clinically relevant model of elevated d-glucose that Akt1 and the post-translational modif...

journal_title：Molecular and cellular endocrinology

authors： Hou J,Chong ZZ,Shang YC,Maiese K

更新日期：2010-06-10 00:00:00

abstract：:Little is known about the regulation and cellular distribution of androgen receptors (ARs) in female rodent brains at various stages of the oestrous cycle. This information is critical for further studies of androgen signalling in the regulation of brain function under physiological and pathophysiological conditions. ...

journal_title：Molecular and cellular endocrinology

authors： Feng Y,Weijdegård B,Wang T,Egecioglu E,Fernandez-Rodriguez J,Huhtaniemi I,Stener-Victorin E,Billig H,Shao R

更新日期：2010-06-10 00:00:00

abstract：:Thyroid oncocytic neoplasms are tumors composed of cells characterized by an aberrant increase of mitochondrial mass. They represent a subset of thyroid tumors whose classification and clinical features has been a matter of controversy for clinicians and pathologists alike. The prevalence of oncocytic tumors in the th...

journal_title：Molecular and cellular endocrinology

authors： Gasparre G,Bonora E,Tallini G,Romeo G

更新日期：2010-05-28 00:00:00

abstract：:TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activ...

journal_title：Molecular and cellular endocrinology

authors： Greco A,Miranda C,Pierotti MA

更新日期：2010-05-28 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a precursor sex steroid, circulates in sulphated form (DHEAS). Serum DHEAS concentrations are inversely correlated with metabolic syndrome components and in vivo/in vitro studies suggest a role in modulating adipose mass. To investigate further, we assessed the in vitro biological effect...

journal_title：Molecular and cellular endocrinology

authors： Rice SP,Zhang L,Grennan-Jones F,Agarwal N,Lewis MD,Rees DA,Ludgate M

更新日期：2010-05-14 00:00:00

abstract：:Glucocorticoids (GCs) are used in combination therapy for treating acute lymphoblastic leukemia (ALL). In T-cell (CEM-C7) and pre-B-cell (697) ALL cell lines, dexamethasone (Dex) treatment causes an auto-upregulation of glucocorticoid receptor (GR) mRNA transcripts and protein. We hypothesized that there is a threshol...

journal_title：Molecular and cellular endocrinology

authors： Schwartz JR,Sarvaiya PJ,Vedeckis WV

更新日期：2010-05-14 00:00:00

abstract：:Adipose tissue develops from differentiating preadipocytes that expand and migrate. 3T3-L1 preadipocytes respond to melanin-concentrating hormone (MCH) by increasing leptin production. Here, we investigate whether MCH elicits remodeling of the actin cytoskeleton and whether this translates into altered migratory capac...

journal_title：Molecular and cellular endocrinology

authors： Cook LB,Shum L,Portwood S

更新日期：2010-05-14 00:00:00

abstract：:In this paper, we identify three different MRAPs in zebrafish, zfMRAP1, zfMRAP2a and zfMRAP2b, and demonstrate that zfMC2R is not functional in the absence of MRAP expression. ZfMRAP1 expression was restricted to adipose tissue and the anterior kidney whereas MRAP2a and MRAP2b were expressed in all the tissues tested....

journal_title：Molecular and cellular endocrinology

authors： Agulleiro MJ,Roy S,Sánchez E,Puchol S,Gallo-Payet N,Cerdá-Reverter JM

更新日期：2010-05-14 00:00:00

abstract：:Insulin-induced glucose uptake by skeletal muscle results from Akt2 activation and is severely impaired during insulin resistance. Recently, we and others have demonstrated that BMP9 improves glucose homeostasis in diabetic and non-diabetic rodents. However, the mechanism by which BMP9 modulates insulin action remains...

journal_title：Molecular and cellular endocrinology

authors： Anhê FF,Lellis-Santos C,Leite AR,Hirabara SM,Boschero AC,Curi R,Anhê GF,Bordin S

更新日期：2010-05-05 00:00:00

abstract：:Transcription elongation of many eukaryotic genes is regulated. Two negative transcription elongation factors, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) are known to stall collaboratively RNA polymerase II promoter proximally. We dis...

journal_title：Molecular and cellular endocrinology

authors： Fujita T,Piuz I,Schlegel W

更新日期：2010-05-05 00:00:00

abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

journal_title：Molecular and cellular endocrinology

authors： Thompson BR,Lobo S,Bernlohr DA

更新日期：2010-04-29 00:00:00

abstract：:Follicle-stimulating hormone (FSH) is essential for primate reproduction and acts via the FSH-receptor (FSHR). Although the FSHR expression is highly cell-specific, knowledge of the FSHR promoter and its transcriptional regulation is very limited. We applied a comparative genomic approach of important primate lineages...

journal_title：Molecular and cellular endocrinology

authors： Brune M,Adams C,Gromoll J

更新日期：2010-04-12 00:00:00

abstract：:Berberine has been shown to have insulin-sensitizing effect, but the molecular mechanism underlying remains elusive. In this work, we investigated the effect of berberine on insulin-induced signal transduction and glucose uptake in both insulin-sensitive and insulin-resistant rat skeletal muscle cells. Berberine incre...

journal_title：Molecular and cellular endocrinology

authors： Liu LZ,Cheung SC,Lan LL,Ho SK,Xu HX,Chan JC,Tong PC

更新日期：2010-04-12 00:00:00

abstract：:In the haematophagous insect, Rhodnius prolixus, a rapid diuresis following engorgement of vertebrate blood is under the control of two main diuretic hormones: a corticotropin-releasing factor (CRF)-related peptide andserotonin (5HT). A CAP2b (CAPA)-related peptide is involved in the termination of this diuresis, and ...

journal_title：Molecular and cellular endocrinology

authors： Paluzzi JP,Orchard I

更新日期：2010-04-12 00:00:00

abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

journal_title：Molecular and cellular endocrinology

authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

更新日期：2010-03-05 00:00:00

abstract：:Sex hormone-binding globulin (SHBG) is the main transport binding protein for sex steroid hormones in plasma and regulates their accessibility to target cells. Plasma SHBG is secreted by the liver under the control of hormones and nutritional factors. In the human hepatoma cell line (HepG2), thyroid and estrogenic hor...

journal_title：Molecular and cellular endocrinology

authors： Pugeat M,Nader N,Hogeveen K,Raverot G,Déchaud H,Grenot C

更新日期：2010-03-05 00:00:00

abstract：:South African Angora goats are susceptible to cold stress, due to their inability to produce sufficient levels of cortisol. During adrenal steroidogenesis the production of cortisol relies on the activity of two key enzymes, namely cytochrome P450 17alpha-hydroxylase and 3beta-hydroxysteroid dehydrogenase. Cytochrome ...

journal_title：Molecular and cellular endocrinology

authors： Goosen P,Swart AC,Storbeck KH,Swart P

更新日期：2010-02-05 00:00:00

abstract：:In type 2 diabetes, a strong correlation between intramyocellular lipid accumulation and insulin resistance exists but whether intramyocellular accumulation is a cause or a consequence of insulin resistance is not clear. Lipid accumulation and response to insulin were evaluated in primary human myotubes derived from n...

journal_title：Molecular and cellular endocrinology

authors： Aguer C,Mercier J,Kitzmann M

更新日期：2010-02-05 00:00:00

abstract：:Expression of the multi-PDZ protein Pdzd2 (PDZ domain-containing protein 2) is enriched in pancreatic islet beta cells, but not in exocrine or alpha cells, suggesting a role for Pdzd2 in the regulation of pancreatic beta-cell function. To explore the in vivo function of Pdzd2, Pdzd2-deficient mice were generated. Homo...

journal_title：Molecular and cellular endocrinology

authors： Tsang SW,Shao D,Cheah KS,Okuse K,Leung PS,Yao KM

更新日期：2010-02-05 00:00:00

abstract：:The availability of regulatory sequences directing tissue-specific expression of transgenes in genetically modified mice and large animals is a prerequisite for the development of adequate models for human diseases. The rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic beta-...

journal_title：Molecular and cellular endocrinology

authors： Grzech M,Dahlhoff M,Herbach N,Habermann FA,Renner-Müller I,Wanke R,Flaswinkel H,Wolf E,Schneider MR

更新日期：2010-02-05 00:00:00

abstract：:Mammalian spermatozoa undergo several signaling and biochemical transformations in the female genital tract, collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, where it undergoes the acrosome reaction (AR), a process enabling it to penetrate and fertilize the egg. Actin pol...

journal_title：Molecular and cellular endocrinology

authors： Breitbart H,Rotman T,Rubinstein S,Etkovitz N

更新日期：2010-01-27 00:00:00

abstract：:Central leptin action requires PI3K activity to modulate glucose homeostasis and peripheral metabolism. However, the mechanism behind this phenomenon is not clearly understood. We hypothesize that hypothalamic PI3K activity is important for the modulation of the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxyla...

journal_title：Molecular and cellular endocrinology

authors： Roman EA,Reis D,Romanatto T,Maimoni D,Ferreira EA,Santos GA,Torsoni AS,Velloso LA,Torsoni MA

更新日期：2010-01-15 00:00:00

abstract：:P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450s and mutations in POR cause several metabolic disorders. We have modeled the structure of human P450 oxidoreductase by in silico amino acid replacements in the rat POR crystal structure. The rat POR has 94% homology with human POR ...

journal_title：Molecular and cellular endocrinology

authors： Flück CE,Mullis PE,Pandey AV

更新日期：2009-12-10 00:00:00

abstract：:A Chinese family with autosomal recessive pituitary dwarfism was identified and the proband was evaluated by MRI and hormonal analysis, which revealed pituitary dwarfism with a complete growth hormone deficiency. MRI showed a pituitary gland with a small anterior pituitary of 2.2mm and evidence of hypoplastic pituitar...

journal_title：Molecular and cellular endocrinology

authors： Wang Q,Diao Y,Xu Z,Li X,Luo XP,Xu H,Ouyang P,Liu M,Hu Z,Wang QK,Liu JY

更新日期：2009-12-10 00:00:00

abstract：:An accurate understanding of the molecular events governing pancreas development can have an impact on clinical medicine related to diabetes, obesity and pancreatic cancer, diseases with a high impact in public health. Until 1996, the main animal models in which pancreas formation and differentiation could be studied ...

journal_title：Molecular and cellular endocrinology

authors： Tiso N,Moro E,Argenton F

更新日期：2009-11-27 00:00:00

abstract：:In the present paper the effects of 17beta-estradiol on the expression of the preprosomatostatin 1 (PSS1) in the orange-spotted grouper hypothalamus and ovary were investigated. Results from in vivo of intraperitoneal injection and in vitro static cultures showed that estradiol increased the mRNA expression of PSS1 ge...

journal_title：Molecular and cellular endocrinology

authors： Zhang L,Li W,Hong X,Lin H

更新日期：2009-11-13 00:00:00

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:The red-spotted grouper, Epinephelus akaara, is a protogynous hermaphroditic fish that shows the characteristic of natural sex change. In this study, 2-year-old female groupers were successfully reversed to functional males by oral administration of 17alpha-methyltestosterone (MT) for 42 days. The protein inhibitor of...

journal_title：Molecular and cellular endocrinology

authors： Li SW,Long ZF,Du J,Liu SG,Wen JJ

更新日期：2009-10-15 00:00:00

abstract：:The rapid effects of steroids on spermatozoa have been demonstrated for the first time two decades ago. Progesterone (P), which is present throughout the female genital tract with peaks of levels in the cumulus matrix surrounding the oocyte, stimulates several sperm functions, including hyperactivation and acrosome re...

journal_title：Molecular and cellular endocrinology

authors： Baldi E,Luconi M,Muratori M,Marchiani S,Tamburrino L,Forti G

更新日期：2009-09-24 00:00:00

abstract：:Endometriosis causes pelvic pain and infertility in women of reproductive age. We explored TNFalpha-induced specific signaling pathways and gene expressions in endometriotic stromal cells (ESCs). Based on the data of the pathway specific cDNA array, we analyzed the role of TAK1, which is believed to work as a common m...

journal_title：Molecular and cellular endocrinology

authors： Taniguchi F,Harada T,Miyakoda H,Iwabe T,Deura I,Tagashira Y,Miyamoto A,Watanabe A,Suou K,Uegaki T,Terakawa N

更新日期：2009-08-13 00:00:00

abstract：:The contributions of prolactin (PRL) to breast cancer are becoming increasingly recognized. To better understand the role for PRL in this disease, its interactions with other oncogenic growth factors and hormones must be characterized. Here, we review our current understanding of PRL crosstalk with other mammary oncog...

journal_title：Molecular and cellular endocrinology

authors： Carver KC,Arendt LM,Schuler LA

更新日期：2009-08-13 00:00:00

abstract：:The nuclear receptor corepressor (NCoR) interacts with the DNA-bound thyroid receptor (TR) homodimer through two of its three receptor-interacting domains (RIDs). One of these RIDs must be the most N-terminal, termed N3, which preferentially works with the next closest RID, N2. Interestingly, the spacing between the R...

journal_title：Molecular and cellular endocrinology

authors： Astapova I,Dordek MF,Hollenberg AN

更新日期：2009-08-13 00:00:00

abstract：:In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between sever...

journal_title：Molecular and cellular endocrinology

authors： Dacheux JL,Belleannée C,Jones R,Labas V,Belghazi M,Guyonnet B,Druart X,Gatti JL,Dacheux F

更新日期：2009-07-10 00:00:00

abstract：:Bone tissue is especially receptive to physical stimulation and agents with the capacity to mimic the signalling incurred via mechanical loading on osteoblasts may find an application in a bone regenerative setting. Recently this laboratory revealed that the major serum lipid, lysophosphatidic acid (LPA), co-operated ...

journal_title：Molecular and cellular endocrinology

authors： Mansell JP,Farrar D,Jones S,Nowghani M

更新日期：2009-06-16 00:00:00

abstract：:Presently, a growing interest is focused on the origins of the "Metabolic Syndrome", a cluster of several metabolic disorders linking obesity, dyslipidemia, hypertension and type 2 diabetes mellitus. Clearly, genetic predisposition and deleterious lifestyle, including low physical activity and hypercaloric alimentatio...

journal_title：Molecular and cellular endocrinology

authors： Somm E,Schwitzgebel VM,Vauthay DM,Aubert ML,Hüppi PS

更新日期：2009-05-25 00:00:00

abstract：:Pro-protein convertase-2 (PC2) and carboxypeptidase-E (CPE) proteins are two major members of the pro-protein convertases that involve in the maturation of protein precursor. By using PC2 activity, immunocytochemistry (ICC) and Western blot method, PC2, CPE and preproNPY protein expression levels were compared among m...

journal_title：Molecular and cellular endocrinology

authors： Tang SS,Zhang JH,Liu HX,Li HZ

更新日期：2009-05-06 00:00:00

abstract：:The angiotensin II (AngII) type 1 (AT(1)) receptor is a seven-transmembrane G protein-coupled receptor, and is involved in regulating the physiological and pathological process of the cardiovascular system. Systemically and locally generated AngII has agonistic action on AT(1) receptor, but recent studies have demonst...

journal_title：Molecular and cellular endocrinology

authors： Akazawa H,Yasuda N,Komuro I

更新日期：2009-04-29 00:00:00

abstract：:In the characterization of newly identified proteins, subcellular localization studies can provide important hints to the proteins' metabolic functions. Depending on the biochemical task of an enzyme, certain subcellular environmental conditions as pH or availability of cofactors and substrates have to be fulfilled. C...

journal_title：Molecular and cellular endocrinology

authors： Keller B,Meier M,Adamski J

更新日期：2009-03-25 00:00:00